Hypertension, or high blood pressure, is a global health challenge affecting over 1.28 billion people worldwide. It is a significant contributor to cardiovascular diseases, stroke, and kidney failure. While lifestyle modifications and medications are effective for many, approximately 10–20% of individuals experience resistant hypertension, a condition where blood pressure remains elevated despite the use of three or more antihypertensive medications. This unmet need has driven interest in innovative therapies, including neural stimulation devices. These devices target the nervous system to modulate blood pressure regulation, offering hope for patients with difficult-to-control hypertension. This article reviews the science, current research, and future potential of neural stimulation devices for hypertension management.
