Hypertension, commonly known as high blood pressure, affects over 1.28 billion people worldwide, making it one of the most prevalent chronic health conditions. Despite advancements in medications and lifestyle interventions, many patients struggle to achieve optimal blood pressure control, particularly those with resistant hypertension. As researchers explore innovative approaches to managing this condition, gene therapy has emerged as a promising frontier. By targeting the genetic mechanisms underlying hypertension, gene-based therapies offer the potential for more precise and long-lasting treatment. This article examines the science behind gene therapy for hypertension, the experimental therapies under development, and the potential challenges and future prospects of this cutting-edge approach.