Hypertension, often called the “silent killer,” is a global health challenge affecting more than 1.28 billion adults worldwide, as reported by the World Health Organization (WHO). Despite advancements in pharmacological treatments and lifestyle interventions, many patients struggle to achieve optimal blood pressure control. Increasing attention has turned to the endothelium, a thin layer of cells lining blood vessels, as a key player in hypertension pathophysiology. Dysfunction of the endothelium is recognized as an early and critical factor in the development and progression of high blood pressure. This article explores how targeting endothelial dysfunction could revolutionize hypertension management, delving into the mechanisms, therapeutic strategies, and emerging treatments aimed at restoring vascular health.
