CRPS is characterized by persistent and severe pain that typically affects one limb, such as an arm, leg, hand, or foot. It usually develops after an injury, surgery, stroke, or heart attack. Despite extensive research, the exact mechanisms behind CRPS are still unclear, which makes it a challenging condition to treat effectively. The pain associated with CRPS is often disproportionate to the initial injury, and patients may experience symptoms like changes in skin color and temperature, swelling, and abnormal sweating.