Autoimmune fatigue is a unique and profound exhaustion that goes beyond regular tiredness. Those who experience it describe a pervasive sense of weariness that is not alleviated by rest or sleep. This fatigue can be both physical and mental, leading to difficulties in concentration, memory lapses, and a general sense of being “out of it”. The severity of autoimmune fatigue can vary from day to day, but it often feels like carrying a heavy weight that makes even simple tasks seem insurmountable.