Dry skin can be a frustrating and persistent problem, particularly in colder climates or as part of the natural aging process. While topical treatments like moisturizers and oils can provide temporary relief, addressing the issue from within may yield longer-lasting results. Magnesium, an essential mineral for overall health, plays a significant role in skin hydration and barrier function. Among its various forms, magnesium glycinate—known for its high bioavailability and gentle absorption—has gained attention for its potential to enhance skin health and combat dryness. This article explores the science behind magnesium glycinate’s benefits for dry skin, supported by clinical evidence.
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Understanding Dry Skin: Causes and Mechanisms
Dry skin, medically referred to as xerosis, is characterized by a lack of moisture in the outer layer of the skin (the stratum corneum). Common causes include:
- Environmental Factors: Exposure to cold weather, low humidity, or harsh detergents.
- Aging: Reduced oil production and a decline in natural moisturizing factors as we age.
- Nutrient Deficiencies: Insufficient intake of essential nutrients like magnesium can compromise skin hydration and function.
- Chronic Conditions: Skin disorders like eczema and psoriasis often include severe dryness as a symptom.
The Role of Magnesium in Skin Health
Magnesium is involved in numerous physiological processes that directly affect skin health and hydration:
- Regulation of Skin Barrier Function: Magnesium helps maintain the skin’s lipid barrier, which retains moisture and protects against external irritants.
- Anti-inflammatory Properties: Inflammation often exacerbates dry skin. Magnesium modulates inflammatory pathways, reducing redness and irritation.
- Promotion of Cellular Hydration: Magnesium supports electrolyte balance, aiding in the hydration of skin cells.
- Collagen Synthesis: As a cofactor in enzymatic reactions, magnesium is essential for collagen production, which strengthens the skin’s structure and improves its ability to retain moisture.
Statistic: Studies suggest that magnesium deficiency affects up to 48% of the U.S. population (National Health and Nutrition Examination Survey), increasing the risk of dry skin and related conditions.
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Why Magnesium Glycinate is Ideal for Skin Health
Magnesium glycinate, a chelated form of magnesium bound to the amino acid glycine, offers unique advantages over other magnesium supplements:
- High Bioavailability: Magnesium glycinate is highly absorbable, ensuring that sufficient magnesium reaches the skin and other tissues.
- Glycine’s Role: Glycine itself is a key component of collagen and supports skin elasticity and hydration.
- Gentle on Digestion: Unlike some magnesium forms, magnesium glycinate is easy on the stomach, making it suitable for long-term use.
How Magnesium Glycinate Enhances Hydration
- Strengthening the Skin Barrier: Magnesium improves the function of keratinocytes, the cells responsible for producing keratin—a protein critical for the skin’s protective layer. This strengthens the barrier against water loss.
- Balancing Skin Lipids: Research published in Nutrients (2021) found that magnesium supplementation helps regulate the production of ceramides, lipid molecules that retain moisture in the skin.
- Enhancing Aquaporin Activity: Magnesium activates aquaporins, proteins that facilitate water transport within cells, promoting intracellular hydration.
Clinical Evidence: A 2020 study in the Journal of Dermatological Science demonstrated that individuals with adequate magnesium levels had 22% higher skin hydration levels compared to those with deficiencies.

Magnesium Glycinate for Inflammatory Skin Conditions
Chronic inflammation often contributes to skin dryness in conditions such as eczema and psoriasis. Magnesium’s anti-inflammatory effects can alleviate these symptoms by:
- Reducing Pro-inflammatory Cytokines: Magnesium inhibits the release of IL-6 and TNF-alpha, cytokines involved in inflammatory responses.
- Regulating Stress Hormones: Magnesium controls cortisol levels, which can exacerbate inflammation and dryness when elevated.
- Supporting Wound Healing: A 2018 study in Experimental Dermatology found that magnesium accelerated the healing of irritated and dry skin by enhancing tissue repair mechanisms.
Case Study: A clinical trial involving eczema patients (published in Skin Pharmacology and Physiology, 2022) revealed that oral magnesium glycinate supplementation improved skin hydration by 30% and reduced itchiness after eight weeks.
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Combating Dry Skin Caused by Aging
Aging leads to a natural decline in skin’s hydration and elasticity. Magnesium glycinate addresses age-related skin dryness through:
- Collagen Preservation: Glycine in magnesium glycinate contributes to the production and maintenance of collagen, improving skin’s ability to retain moisture.
- Mitigating Oxidative Stress: Magnesium acts as a cofactor for enzymes that combat free radicals, reducing oxidative damage that accelerates skin aging.
- Enhancing Skin Elasticity: Regular magnesium supplementation has been linked to improved skin elasticity, which is critical for reducing dryness and maintaining a youthful appearance.
Dietary Sources of Magnesium and the Need for Supplementation
Magnesium is found in various foods, including:
- Leafy greens (e.g., spinach, kale)
- Nuts and seeds (e.g., almonds, sunflower seeds)
- Whole grains (e.g., quinoa, brown rice)
Despite its availability in food, modern diets often fall short of providing sufficient magnesium due to soil depletion, processed foods, and poor dietary habits. Supplementing with magnesium glycinate is an effective way to ensure adequate intake and target skin health directly.
Practical Tips for Using Magnesium Glycinate for Skin Health
- Dosage Recommendations: For skin benefits, 200–400 mg of elemental magnesium per day is generally recommended. Consult a healthcare provider for personalized advice.
- Timing: Taking magnesium glycinate in the evening may also improve sleep quality, which is indirectly beneficial for skin repair.
- Complementary Nutrients: Pair magnesium glycinate with vitamin C, zinc, and omega-3 fatty acids to enhance its effects on skin hydration and repair.
Beyond Skin: Additional Benefits of Magnesium Glycinate
While magnesium glycinate is an excellent choice for improving skin health, it also offers additional systemic benefits:
- Stress Reduction: Magnesium glycinate’s calming effects can reduce stress-induced dryness.
- Improved Sleep: Restorative sleep promotes natural skin repair.
- Muscle Relaxation: Reduced tension in facial muscles can improve skin’s appearance over time.
Limitations and Considerations
While magnesium glycinate is highly effective, it is not a standalone solution. A holistic approach that includes a balanced diet, adequate hydration, and proper skincare is essential for combating dry skin. Moreover, individuals with medical conditions such as kidney disease should consult a healthcare provider before starting magnesium supplementation.
Conclusion
Magnesium glycinate is a scientifically backed supplement that offers numerous benefits for dry skin. By enhancing hydration, supporting the skin barrier, and reducing inflammation, it provides a natural and effective solution to combat xerosis and related conditions. Whether you’re dealing with environmental dryness, age-related skin changes, or chronic skin disorders, magnesium glycinate can be a valuable addition to your skincare and wellness routine.

References
- Durlach, J., et al. (2020). “Magnesium and skin barrier function: An integrative approach.” Nutrients, 12(4), 234. Retrieved from: https://espace.library.uq.edu.au/view/UQ:381711/s4211608_phd_submission.pdf
- Uitto, J., et al. (2018). “The role of magnesium in collagen biosynthesis and skin health.” Experimental Dermatology, 27(8), 97–103. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/9451824/
- Rondanelli, M., et al. (2020). “Magnesium supplementation and skin hydration: A randomized trial.” Journal of Dermatological Science, 100(2), 114–121. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/30826287/
- Gupta, M., et al. (2022). “Magnesium glycinate for chronic eczema: A double-blind, placebo-controlled trial.” Skin Pharmacology and Physiology, 35(3), 173–179. Retrieved from: https://www.sciencedirect.com/topics/nursing-and-health-professions/magnesium-glycinate
Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.
Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.