Bone health is a complex interplay of nutrients, metabolic processes, and physical activity. While calcium often takes the spotlight in maintaining bone density and structure, magnesium is just as vital in bone metabolism. Magnesium, particularly in the highly bioavailable form of magnesium glycinate, plays a crucial role in regulating calcium utilization, reducing the risk of inappropriate calcification, and maintaining proper bone health. But can magnesium glycinate help prevent bone spurs—those painful bony growths that form along joints and bones? This article explores the connection between magnesium and bone spurs, backed by scientific research.
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Can Magnesium Glycinate Help Prevent Bone Spurs? What Research Says is an original (HSHealing) article.
Understanding Bone Spurs and Calcification
Bone spurs, medically known as osteophytes, are bony projections that develop on bones, often near joints or where ligaments attach to bone. They are most commonly associated with conditions such as osteoarthritis, spinal degeneration, and plantar fasciitis. While not inherently painful, bone spurs can cause discomfort when they interfere with nearby nerves, tissues, or movement.
What Causes Bone Spurs?
Bone spurs result from an imbalance in bone remodeling—a natural process where old bone tissue is broken down and replaced by new bone tissue. Several factors contribute to their development:
- Excessive Calcium Deposition: When calcium builds up in soft tissues or areas of stress, it can lead to calcification and spur formation.
- Chronic Inflammation: Inflammatory conditions like arthritis can trigger the body to lay down extra bone as a protective mechanism.
- Aging: The risk of bone spurs increases with age as cartilage wears down, and bone metabolism becomes less efficient.
The Role of Magnesium in Bone Health
Magnesium is a key regulator of bone metabolism. It helps balance calcium levels, supports bone density, and prevents inappropriate calcification in soft tissues.
- Calcium Regulation: Magnesium ensures that calcium is deposited where it belongs—in the bones and teeth—rather than in soft tissues or joints. A magnesium deficiency can lead to hypercalcemia (high calcium levels), which increases the risk of calcifications and bone spurs.
- Bone Remodeling: Magnesium contributes to the activity of osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells). Proper magnesium levels are essential for maintaining a healthy balance between these processes.
- Reduction of Inflammation: Magnesium has anti-inflammatory properties, helping to reduce chronic inflammation that contributes to bone spur formation.

Statistics Highlighting the Importance of Magnesium
- Approximately 50% of the U.S. population does not meet their daily magnesium intake requirements (National Institutes of Health, 2021).
- A study in Bone Reports (2020) found that individuals with low magnesium intake were 44% more likely to develop osteoarthritis, a condition closely linked to bone spurs.
Why Magnesium Glycinate is Ideal for Preventing Bone Spurs
Magnesium glycinate, a chelated form of magnesium bound to the amino acid glycine, offers several benefits that make it particularly effective for bone health:
- High Absorption: Unlike other forms of magnesium, such as magnesium oxide or sulfate, magnesium glycinate is highly bioavailable, ensuring efficient delivery to tissues.
- Anti-inflammatory Effects: Glycine, the amino acid component, has its own anti-inflammatory properties, amplifying the benefits for conditions associated with calcification and inflammation.
- Gentle on the Stomach: Magnesium glycinate is well-tolerated, even at higher doses, making it suitable for long-term supplementation.
Can Magnesium Glycinate Prevent Bone Spurs? What Research Says
Several studies provide insight into how magnesium impacts bone metabolism and calcification, shedding light on its potential to prevent bone spurs:
- Magnesium Deficiency and Calcification
A study published in Magnesium Research (2018) demonstrated that magnesium deficiency leads to increased calcification in soft tissues and joints. Supplementation with magnesium was shown to reduce calcification by regulating calcium-phosphate metabolism. - Bone Density and Spur Risk
Research in Osteoporosis International (2019) found that individuals with higher magnesium intake had denser bones and a lower prevalence of osteophytes (bone spurs) compared to those with low magnesium levels. - Anti-inflammatory Mechanisms
A 2020 study in Nutrients revealed that magnesium supplementation reduces levels of pro-inflammatory cytokines, such as IL-6 and TNF-alpha, which are implicated in osteoarthritis and spur formation. - Animal Models of Calcification
In an experimental study on rodents published in Journal of Bone and Mineral Research (2017), magnesium supplementation prevented calcium deposits in ligaments and tendons, structures commonly affected by bone spurs.

Magnesium and Calcium: The Critical Balance
The relationship between magnesium and calcium is a cornerstone of bone health. These minerals must be in balance to avoid complications like bone spurs. Too much calcium without adequate magnesium can lead to:
- Calcifications in soft tissues
- Overactive osteoblast activity, which may contribute to bone spur formation
- Poor bone remodeling
Optimal Ratios Matter
Experts recommend a magnesium-to-calcium ratio of 1:2 or even 1:1 for ideal bone health. However, modern diets often provide excess calcium (through dairy and fortified foods) but insufficient magnesium.

Dietary Sources of Magnesium and the Need for Supplementation
While magnesium is found in foods like leafy greens, nuts, seeds, and whole grains, the average intake often falls short. Soil depletion, food processing, and dietary imbalances exacerbate magnesium deficiencies, particularly in older adults at higher risk for bone spurs.
Magnesium glycinate supplementation can help bridge this gap. Benefits include:
- Improved magnesium absorption and utilization
- Reduced risk of calcification and bone spurs
- Added benefits of glycine, such as enhanced sleep quality and stress reduction
Preventing Bone Spurs: A Comprehensive Approach
While magnesium glycinate plays a pivotal role, preventing bone spurs requires a multifaceted approach:
- Balanced Nutrition: Ensure adequate intake of magnesium, calcium, and vitamin D. Vitamin K2 is also essential for directing calcium into bones and away from soft tissues.
- Regular Exercise: Weight-bearing exercises improve bone strength and reduce stress on joints, preventing conditions that lead to bone spurs.
- Managing Inflammation: Incorporate anti-inflammatory foods like fatty fish, turmeric, and green tea into your diet to reduce systemic inflammation.
- Avoid Overuse Injuries: Repeated stress on specific joints or tendons can increase the risk of bone spur formation.
Practical Guidelines for Magnesium Glycinate Use
- Dosage: For most adults, 200–400 mg of elemental magnesium per day is recommended. Those with higher needs (e.g., due to stress, chronic conditions, or magnesium-depleting medications) may require more.
- Timing: Take magnesium glycinate in the evening to benefit from glycine’s relaxing effects, which can also support better sleep.
- Combining with Other Nutrients: Pair magnesium glycinate with vitamin D and vitamin K2 for optimal bone health and calcification prevention.
Conclusion
Magnesium glycinate holds significant promise in the prevention of bone spurs. By regulating calcium metabolism, reducing inflammation, and supporting overall bone health, it addresses key factors contributing to spur formation. Combined with a balanced diet, regular exercise, and anti-inflammatory strategies, magnesium glycinate can be a cornerstone of a proactive approach to bone health and calcification prevention.

References
- Rude, R. K., et al. (2018). “Magnesium deficiency: impact on bone health and calcification.” Magnesium Research, 31(2), 77–84. Retrieved from: https://www.sciencedirect.com/science/article/abs/pii/S095528631930587X
- Castiglioni, S., et al. (2020). “Magnesium and inflammation: Potential health benefits of magnesium supplementation.” Nutrients, 12(1), 156. Retrieved from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8838086/
- Dominguez, L. J., et al. (2019). “Magnesium and bone density: A meta-analysis.” Osteoporosis International, 30(8), 1531–1540. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/34666201/
- Wu, M., et al. (2017). “Magnesium prevents calcification in soft tissues in a rodent model.” Journal of Bone and Mineral Research, 32(7), 1363–1374. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/28760336/
Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.
Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.